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目的:观察注射用白眉蛇毒血凝酶治疗早产儿消化道出血的疗效。方法:将符合早产儿消化道出血诊断标准的82例患儿随机分为观察组和对照组各41例。两组患儿均给予维生素K1、酚磺乙胺、西咪替丁静脉滴注,1次/天,连用3~5 d,若出血量大者可予输新鲜冰冻血浆;观察组在此基础上给予注射用白眉蛇毒血凝酶0.5 k U胃管注入,同时0.5 k U静脉推注,根据出血情况,1~6 h可重复一次,共2~4次,直至出血停止。结果:观察组总有效率92.7%,对照组总有效率56.1%,两组比较差异有统计学意义(P<0.05)。观察组在治疗过程中未见明显不良反应。结论:注射用白眉蛇毒血凝酶治疗早产儿消化道出血疗效显著,未见明显不良反应,可作为早产儿消化道出血常规用药。
Objective: To observe the efficacy of injection of white eyebrow venom hemagglutinin in the treatment of gastrointestinal bleeding in premature infants. Methods: 82 children who meet the diagnostic criteria for gastrointestinal bleeding in preterm infants were randomly divided into observation group and control group, 41 cases each. The two groups of children were given vitamin K1, metsulfuron-methyl, cimetidine intravenous infusion, 1 / day, once every 3 ~ 5 d, if the bleeding large can be transported fresh frozen plasma; observation group based on this On the injection of white eyebrow venom hemolytic enzyme 0.5 kU gastric tube injection, while 0.5 kU intravenous injection, according to the bleeding, 1 ~ 6 h can be repeated once, a total of 2 to 4 times until the bleeding stopped. Results: The total effective rate was 92.7% in the observation group and 56.1% in the control group, with significant difference between the two groups (P <0.05). Observation group in the course of treatment showed no significant adverse reactions. Conclusion: The injection of white eyebrow venom hemagglutinin treatment of preterm children with gastrointestinal bleeding significant effect, no obvious adverse reactions, can be used as a routine prenatal gastrointestinal bleeding.