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普萘洛尔治疗婴幼儿血管瘤(IH)的机制尚不清楚。该文作者假设这一非选择性β受体阻滞剂通过下调肾素-血管紧张素-醛固酮(RAA)轴系统的表达,抑制血管新生,促进IH消退。手术获取普萘洛尔治疗和未治疗的IH患者标本及血清,以患者正常皮肤组织作为对照。反转录聚合酶链反应和蛋白免疫印迹检测增殖期(n=10)IH、消退期IH(n=10)、普萘洛尔治疗后IH(n=12)和正常皮肤组织标本(n=11)中的RAA。血清标本采用ELISA分析。结果:增殖期标本中血管紧张素原(AGT)m RNA表达水平显
The mechanism of propranolol in the treatment of infantile hemangiomas (IH) is unclear. The authors hypothesize that this non-selective beta-blocker inhibits angiogenesis and promotes IH regress by downregulating the renin-angiotensin-aldosterone (RAA) axis system. Surgical removal of propranolol and untreated IH patients with serum samples and normal skin tissue as a control. Reverse transcription polymerase chain reaction (RT-PCR) and Western blotting were used to detect the proliferative phase (n = 10) IH, regression IH (n = 10), propranolol IH (n = 12) and normal skin tissue (n = 11) in the RAA. Serum samples were analyzed by ELISA. Results: The expression of angiotensinogen (AGT) m RNA in proliferative phase was significantly higher than that in control group