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目的了解隆回县艾滋病抗病毒治疗效果和药物不良反应发生情况。方法对县CDC连续抗病毒治疗>12个月的115例HIV/AIDS患者资料进行回顾性分析。结果 115例患者治疗6个月与治疗前、治疗12个月与治疗6个月比较,CD4细胞计数均有上升;与治疗前基线比较,治疗6个月或12个月的CD4细胞计数均有上升,但组间CD4细胞计数增加值差异无统计学意义;治疗后病毒完全抑制者占72.2%(83/115),不同治疗时间病毒完全抑制差异无统计学意义;服药后主要不良反应为食欲改变、恶心呕吐、疲倦、眩晕和皮疹等,经及时处理,大多在治疗3个月内减轻或消除,治疗1年后极少发生不良反应。结论隆回县艾滋病患者抗病毒治疗效果显著,但需进一步加强随访监测,及时处理各种不良反应。
Objective To understand the effects of HIV antiviral therapy and adverse drug reactions in Longhui County. Methods A retrospective analysis of 115 cases of HIV / AIDS patients with CDC continuous anti-virus therapy> 12 months was conducted. Results The counts of CD4 in 115 patients increased 6 months after treatment compared with those before treatment, 12 months after treatment and 6 months after treatment. Compared with baseline before treatment, the counts of CD4 cells in 6 months or 12 months after treatment were , But no significant difference was found in the increase of CD4 count between groups. After treatment, 72.2% (83/115) showed complete inhibition of virus. There was no significant difference in complete inhibition of virus at different treatment time. The main adverse reactions were appetite Change, nausea and vomiting, fatigue, dizziness and rash, etc., after timely treatment, mostly in the treatment of 3 months to reduce or eliminate the treatment of minimal adverse reactions after 1 year. Conclusion The anti-virus treatment of AIDS patients in Longhui County is significant. However, it is necessary to further strengthen follow-up monitoring and timely treatment of various adverse reactions.