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在临床上,确定为遗传病因的皮肤病已经超过200种.近年来遗传学的迅速发展,要求皮肤科医生熟悉现代的遗传学原理及其与皮肤病的关系,以便能顺利地阅读文献并提高处理遗传性疾病的能力.概述1.DNA:遗传密码贮存于DNA中,基因就是DNA分子的某一片段.DNA在DNA聚合酶的作用下进行精确的复制,使有丝分裂所产生的子细胞得到相同的遗传信息.DNA能被多种环境因子所损伤,但它能很有效地修复.着色性干皮症的细胞在其DNA受紫外线损伤后不能充分地修复.还有些皮肤病DNA修复存在障碍,可导致变性和恶变.
Clinically, the number of dermatoses identified as genetic causes has exceeded 200. The rapid advances in genetics in recent years have required dermatologists to be familiar with the modern principles of genetics and their relationship to dermatology so that the literature can be read and improved The ability to deal with hereditary diseases Overview 1.DNA: The genetic code is stored in DNA and the gene is a fragment of a DNA molecule that is precisely replicated under the action of a DNA polymerase so that the daughter cells produced by mitosis get the same DNA can be damaged by a variety of environmental factors, but it can be effectively repaired.Colorized dry skin cells in the DNA damage by UV can not be fully repaired.Some skin disorders have DNA repair obstacles, Can lead to degeneration and malignant transformation.