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目的：观察乌司他丁治疗重症脓毒血症的疗效。方法将入选的50例重症脓毒血症患者,随机分成试验组和对照组,各25例。对照组采用常规的治疗方案,而试验组在此基础上加用乌司他丁。经不同治疗后,对两组患者恢复情况及血小板变化情况进行比较分析。结果经过7 d治疗后,试验组好转率48.00%,明显高于对照组16.00%,两组比较差异有统计学意义(=11.111,=0.001)；试验组死亡率16%明显低于对照组36.00%,两组比较差异有统计学意义(=13.000,=0.000)；治疗过程中试验组患者未出现严重不良反应,经处理后均可耐受。结论乌司他丁在重症脓毒血症治疗中效果显著,可明显改善预后,降低死亡率。“,”Objective To study the clinical effect ulinastatin in the treatment of severe septicopyemia.Methods A total of 50 patients with severe septicopyemia were randomly divided into experimental group and control group with 25 cases in each group. The control group received conventional treatment alone ,while the experimental group received ulinastatin in addition to conventional treatment.After different treatment, comparisonswere made on the rehabilitation condition and adverse reactions between the two groups. Results After 7-day treatment, the experimental group had better improvement rate as 48.00%than 16.00%of the control group, and the difference had statistical significance (χ2=11.111, =0.001) . The experimental group had lower death rate as 16.00% than 36.00% of control group, and the difference had statistical significance (χ2=13.000, =0.000). The experimental group had no severe adverse reactions, which were tolerable after management. Conclusion Ulinastatin can remarkably improve prognosis and reduce death rate in the treatment of severe septicopyemia, and it is worthy of clinical promotion and application.