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目的观察泮托拉唑纳治疗十二指肠溃疡的临床疗效及安全性。方法将经胃镜证实的十二指肠溃疡患者随机分为泮托拉唑组(治疗组60例)与奥美拉唑组(对照组58例)。治疗组应用泮托拉唑40mg,睡前服,对照组用奥美拉唑20mg睡前服,治疗4周,停药后均复查胃镜,观察溃疡愈合情况。治疗期间每周随访1次,并记录症状改善情况及不良反应。结果十二指肠溃疡的愈合率两组分别为91.7%和94.7%。结论泮托拉唑治疗十二指肠溃疡的治愈率和改善率疗效与奥美拉唑相当,其不良反应少,患者耐受性好。
Objective To observe the clinical efficacy and safety of pantoprazole in the treatment of duodenal ulcer. Methods Patients with duodenal ulcer confirmed by endoscopy were randomly divided into pantoprazole group (60 cases) and omeprazole group (58 cases). The treatment group used pantoprazole 40mg, before going to bed service, the control group with omeprazole 20mg bedtime service for 4 weeks, after stopping the gastroscope were reviewed, observe the ulcer healing. Weekly treatment during treatment 1, and record the symptoms and adverse reactions. Results The healing rate of duodenal ulcer was 91.7% and 94.7% in the two groups respectively. Conclusions The cure rate and improvement rate of pantoprazole in the treatment of duodenal ulcer are comparable with that of omeprazole, with less adverse reactions and good patient tolerance.