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近30年已证实60％～80 ％肝硬变患者有糖耐量减低,其中10％～30％最终发展成症状明显的糖尿病,由此可认为肝硬变是一种引起糖尿病的危险因素。如果肝硬变患者(1)肝硬变的诊断至少在糖尿病开始前5年已确立;(2)无家庭Ⅱ型(或Ⅰ型)糖尿病史存在;(3)无其它已知因素逆向影响葡萄糖代谢,如肥胖、营养不良等;(4)排除血色病和胰腺外分泌功能失调等,则提示这种继发于慢性肝实质损害而发生的糖尿病为肝原性糖尿病或肝性糖尿病。其发病机理推测与以下几个方面有关:
Nearly 30 years has confirmed that 60% to 80% of patients with liver cirrhosis have impaired glucose tolerance, of which 10% to 30% eventually developed into symptoms of diabetes, which can be considered cirrhosis is a risk factor for diabetes. If cirrhosis patients (1) the diagnosis of cirrhosis at least 5 years before the start of diabetes has been established; (2) no family type II (or type I) diabetes history; (3) no other known factors reverse the impact of glucose Metabolism, such as obesity, malnutrition, etc .; (4) exclude hemochromatosis and pancreatic exocrine dysfunction, etc., suggesting that secondary to chronic liver damage caused by the occurrence of diabetes is hepatic diabetes or hepatic diabetes. The pathogenesis of speculation related to the following aspects: