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目的比较瑞舒伐他汀与阿托伐他汀对急性心肌梗死(AMI)患者的血清胆固醇(TC)、低密度脂蛋白(LDL-C)、高敏C-反应蛋白(hs-CRP)、可溶性白细胞分化抗原40配体(sCD40L)和脂联素(APN)水平的影响。方法选择54例AMI患者,随机分为瑞舒伐他汀组(瑞舒伐他汀10～20mg,qd,28例)和阿托伐他汀组(阿托伐他汀20～40mg,qd,26例),分别检测治疗前及治疗4周后2组患者TC、LDL-C、hs-CRP、sCD40L和APN水平。结果瑞舒伐他汀组和阿托伐他汀组治疗后血清TC、LDL-C、hs-CRP、sCD40L水平较治疗前明显降低,APN水平明显升高,差异有统计学意义(P<0.05)。治疗4周后瑞舒伐他汀组血清hs-CRP、sCD40 L水平与阿托伐他汀组相比明显降低,APN水平明显升高,差异有统计学意义(P<0.05)。结论瑞舒伐他汀和阿托伐他汀都能降低TC、LDL-C、sCD40L、hs-CRP水平,升高APN水平,但瑞舒伐他汀治疗急性心肌梗死的效果明显优于阿托伐他汀。
Objective To compare the effects of rosuvastatin and atorvastatin on serum cholesterol, low density lipoprotein (LDL-C), high-sensitivity C-reactive protein (hs-CRP), and soluble leukocyte differentiation in patients with acute myocardial infarction (AMI) Effects of antigens 40 ligand (sCD40L) and adiponectin (APN) levels. Methods Fifty-four patients with AMI were randomly divided into two groups: rosuvastatin group (rosuvastatin 10 ~ 20mg, qd, n = 28) and atorvastatin group (atorvastatin 20 ~ 40mg, qd, The levels of TC, LDL-C, hs-CRP, sCD40L and APN in two groups before and after treatment for 4 weeks were detected respectively. Results The levels of TC, LDL-C, hs-CRP and sCD40L in rosuvastatin group and atorvastatin group were significantly lower than those before treatment and the APN level was significantly increased (P <0.05). Serum levels of hs-CRP and sCD40 L in the rosuvastatin group were significantly lower than those in the atorvastatin group after 4 weeks of treatment, and APN levels were significantly increased (P <0.05). Conclusion Both rosuvastatin and atorvastatin can reduce the levels of TC, LDL-C, sCD40L and hs-CRP, and increase the level of APN. However, rosuvastatin is superior to atorvastatin in the treatment of acute myocardial infarction.