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目的 探讨VEGF12 1血管生成因子在胃癌中的表达与胃癌微血管密度及胃癌临床病理特征的关系。方法 采用免疫组织化学方法对 5 9例胃癌、2 5例胃慢性良性病变、15例癌旁正常胃黏膜组织检测VEGF12 1阳性表达及微血管密度 (CD34标记 )。结果 (1)胃癌中VEGF12 1阳性表达率为 79 6 6 % (4 7/5 9) ,高于胃慢性良性病变和癌旁正常组织 (P <0 0 5 ) ;胃癌微血管密度 (MVD)高于胃慢性良性病变和癌旁正常组织 (P <0 0 5 )。 (2 )胃癌中VEGF12 1阳性表达率在不同浸润深度组和有无远处转移组有显著性差异 (P <0 0 5 )。胃癌中微血管数量增加 ,形态结构异常 (P <0 0 5 )。结论 VEGF12 1在胃癌中高表达 ,并与胃癌的浸润转移一致。检测VEGF12 1在胃癌中的表达对判断胃癌的恶性程度有价值。
Objective To investigate the relationship between the expression of angiogenesis factor VEGF12 1 in gastric cancer and the microvessel density and the clinicopathological features of gastric cancer. Methods Immunohistochemistry was used to detect the expression of VEGF12 1 and microvessel density (CD34) in 59 cases of gastric cancer, 25 cases of chronic benign gastric lesions, and 15 cases of normal gastric mucosa. Results (1) The positive expression rate of VEGF12 1 in gastric cancer was 79 6 6 % (47/5 9), which was higher than that of chronic benign lesions and adjacent normal tissues (P <0 05). The microvessel density (MVD) of gastric cancer was high. In chronic gastric benign lesions and adjacent normal tissues (P <0 05). (2) The positive rate of VEGF12 1 expression in gastric cancer was significantly different in different depth of invasion group and distant metastasis group (P <0 05). The number of microvessels increased and the morphological structure was abnormal in gastric cancer (P < 0.05). Conclusion VEGF12 1 is highly expressed in gastric cancer and is consistent with the invasion and metastasis of gastric cancer. Detecting the expression of VEGF12 1 in gastric cancer is valuable for judging the malignant degree of gastric cancer.