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目的探讨应用头孢哌酮钠出现双硫仑样不良反应的发生机制以及应对措施。方法本组病例病史明确,诊断清楚后分别给予吸氧、抗过敏、血管活性药物应用等对症治疗。结果经对症处理后,其所出现的双硫仑样不良反应均在2~8 h内得到缓解。结论临床上使用此类抗生素时,应注意此不良反应,同时,注意嘱咐患者在治疗期间及治疗终结后,至少10 d内禁用含乙醇的药物、饮品及食品,以避免发生双硫仑样不良反应,一旦出现此不良反应主要是给予吸氧、抗过敏及对症处理。
Objective To investigate the mechanism of disulfiram-like adverse reactions of cefoperazone sodium and its countermeasures. Methods The history of this group of patients with a clear diagnosis were given after oxygen, anti-allergy, vasoactive drugs such as symptomatic treatment. The results of symptomatic treatment, its occurrence of disulfiram-like adverse reactions were eased within 2 ~ 8 h. Conclusions In the clinical use of such antibiotics, attention should be paid to this adverse reaction. At the same time, care should be taken to instruct patients to disable alcohol-containing drugs, drinks and foods for at least 10 days during and after treatment to avoid disulfiram-like dysfunction Reaction, once this adverse reaction is mainly given oxygen, anti-allergy and symptomatic treatment.