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背景:舒张功能障碍可能是介于高血压与心力衰竭之间的重要病理生理中间状态。本研究旨在确定肾素-血管紧张素-醛固酮系统抑制剂(可减轻心室肥厚和心肌纤维化)是否较其他的抗高血压药物能更大程度地改善舒张功能。方法:随机分配具有舒张功能障碍表现的高血压患者服用血管紧张素受体拮抗剂缬沙坦(逐步增加剂量至320mg1次/d)或匹配的安慰剂。两组患者均同时接受不抑制肾素-血管紧张素系统的抗高血压药
Background: Diastolic dysfunction may be an important pathophysiological intermediate between hypertension and heart failure. This study aimed to determine whether renin-angiotensin-aldosterone system inhibitors (to reduce ventricular hypertrophy and myocardial fibrosis) can improve diastolic function to a greater extent than other antihypertensive drugs. METHODS: Hypertensive patients randomly assigned to have diastolic dysfunction were given either angiotensin receptor antagonist valsartan (stepwise to 320 mg once daily) or matched placebo. Both groups also received antihypertensive drugs that did not inhibit the renin-angiotensin system