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作者按二噁(口英)类分子中氯原子的结合位置,研究了二噁(口英)及二苯并呋喃中毒性较低的化合物如1,3,6,8-四氯二苯并-P-二噁(口英)(1,3,6,8-TCDD)、2,4,6,8-四氯二苯并呋喃(2,4,6,8-TCDF) 以及二噁(口英)中在人体内水平较高的八氯二苯并-P-二噁(口英)(OCDD)对人淋巴培养细胞芳烃羟化酶(AHH)活性的影响。为了比较,作者又研究二噁(口英)及多氯联苯(PCBs)中毒性较高的异构体之一,2,3,7,8-TCDD及3,4,5,3′,4′,5′-六氯联苯(HCB)对AHH活性的影响。以丙酮为溶剂处理的淋巴培养细胞的AHH基础活性为1,以有机氯化物处理的AHH活性与基础活
According to the binding position of chlorine atoms in dioxins, the authors studied the effects of dioxins and dibenzofurans toxic compounds such as 1,3,6,8-tetrachlorodibenzo (1,3,6,8-TCDD), 2,4,6,8-tetrachlorodibenzofuran (2,4,6,8-TCDF), and dioxin Effects of octaclorodibenzo-p-dioxin (OCDD) in human body on the activity of aromatic hydroxylase (AHH) in human lymphocytes cultured in vitro and in vivo. For comparison, the authors studied one of the isoxic, dioxin and PCBs poisoned 2,3,7,8-TCDD and 3,4,5,3 ’ Effect of 4 ’, 5’-Hexachlorobiphenyl (HCB) on AHH Activity. The AHH basal activity of lymphatic cells treated with acetone was 1, the activity of AHH treated with organic chloride and the basal activity