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目的探究血清产前筛查高风险指标与妊娠并发症的相关性,为产前筛查高风险的孕妇进行更全面的孕期保健咨询及有效监测提供依据。方法对宁波市2009年10月至2012年3月的95449名经孕中期产前筛查,孕期随访资料完整,并结束妊娠的妇女,分别按高风险和低风险组,统计妊娠并发症(妊娠期高血压疾病、胎儿窘迫、胎儿生长受限、羊水过少)的发生情况,并进行χ2检验,以P<0.05为差异有统计学意义。结果 95449名孕妇中,发生妊娠并发症1995例,妊娠并发症的发生率为2.09%,其中产前筛查高风险孕妇3818例,发生妊娠并发症196例,发生率为5.13%,低风险孕妇91631例,发生妊娠并发症1799名,发生率为1.96%(χ2=180.012,P<0.001)。高风险和低风险组的妊娠期高血压疾病发生率分别为1.62%和0.68%(χ2=45.668,P<0.001),胎儿窘迫发生率为0.47%和0.13%(χ2=31.552,P<0.001),胎儿生长受限发生率为1.28%和0.35%(χ2=82.641,P<0.001),羊水过少的发生率为1.75%和0.8%(χ2=39.369,P<0.001),差异均有统计学意义。结论产前筛查高风险指标与妊娠并发症有关联,产前筛查高风险孕妇发生妊娠并发症的风险明显高于低风险孕妇,应加强这一人群的监测和保健指导。
Objective To explore the correlation between high risk serum prenatal screening risk indicators and pregnancy complications and to provide evidence for more comprehensive prenatal care consultation and effective monitoring of prenatal screening high risk pregnant women. Methods A total of 95 449 prenatal screening during the second trimester of pregnancy from October 2009 to March 2012 in Ningbo City were enrolled in this study. The women with complete follow-up during pregnancy and the end of pregnancy were enrolled in the high-risk and low-risk groups respectively. Pregnancy complications Hypertensive disease, fetal distress, fetal growth restriction, oligohydramnios) and the occurrence of χ2 test, P <0.05 was considered statistically significant. Results Of 95449 pregnant women, 1995 cases of pregnancy complications occurred, the incidence of pregnancy complications was 2.09%. Among them, 3818 cases of high risk pregnant women were prenatal screening, 196 cases of pregnancy complications occurred, the incidence rate was 5.13%. Low risk pregnant women In the 91631 cases, 1799 pregnancy complications occurred, with a rate of 1.96% (χ2 = 180.012, P <0.001). The incidences of gestational hypertension were 1.62% and 0.68% in the high-risk and low-risk groups (χ2 = 45.668, P <0.001). The incidences of fetal distress were 0.47% and 0.13% (χ2 = 31.552, , The incidence of fetal growth restriction was 1.28% and 0.35% (χ2 = 82.641, P <0.001), the incidence of oligohydramnios was 1.75% and 0.8% (χ2 = 39.369, P <0.001) significance. Conclusion The high risk of prenatal screening is associated with pregnancy complications. The risk of prenatal screening for pregnant women with high risk of pregnancy is significantly higher than that of low risk pregnant women. Monitoring and health care guidance should be strengthened in this population.