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20世纪80年代。静脉滴注免疫球蛋白(intra- venous immune globulin,IVIg)开始被用于免疫缺陷病的治疗,由于其不良反应小。应用较为广泛。在神经系统疾病中。吉兰-巴雷综合征(Guillain-Barrésyndrome,GBS)、慢性炎症性脱髓鞘性多发性神经病(chronic inflammatory demyelinating polyneuropathy,CIDP)、多灶性运动神经病(multifocal motor neuropa- thy,MMN)、重症肌无力(myasthenia gravis,MG)及多发性硬化(multiple selerosis,MS)等发病均涉及免疫机制,经过IVIg治疗,特别是多项随机对照的临床试验,显示了IVIg的有效性,为临床应用提供了循证医学的依据。
1980s. Intravenous immune globulin (IVIg) began to be used in the treatment of immunodeficiency disease due to its small adverse reaction. More widely used. In nervous system diseases. Guillain-Barre syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), multifocal motor neuropa- thy (MMN), severe disease Immune mechanisms are involved in the pathogenesis of myasthenia gravis (MG) and multiple selerosis (MS). After IVIg treatment, especially in a number of randomized controlled clinical trials, the effectiveness of IVIg is demonstrated for clinical application Evidence based medicine.