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前言化合物的生物活性往往由它们的立体选择性所决定。手性物质可能具有显然不同的生理活性或强度。所以某个光学异构体(对映异构体)呈现某种所需要的疗效,而另外一构型能引起相反的作用,甚至毒性。如反应停,只有R-(+)-构型具有催眠作用,而S-(一)-构型致畸。心得安的光学异构体呈现不同的效价,S-异构体作用要比R-构型强100倍。人体内也存在着许多具有不对称中心结构的化合物。于是出现了两种构型,它们互为镜像。这些光学异构体中,通常只有一种构
Preface The biological activity of compounds is often determined by their stereoselectivity. Chiral substances may have apparently different physiological activities or intensities. So one of the optical isomers (enantiomers) has the desired therapeutic effect, while the other configuration can cause the opposite effect, and even toxicity. If the reaction stopped, only the R - (+) - configuration hypnotic effect, and S- (a) - configuration teratogenic. Enantiopure optical isomers show different potency, S-isomer effect than R-configuration 100 times stronger. There are many compounds in the human body that have an asymmetric central structure. So there are two configurations, they are mirror images of each other. Of these optical isomers, there is usually only one configuration