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目的探讨超敏C反应蛋白(hs-CRP)与冠心病严重程度的关系。方法采用IMMAGE全自动特种蛋白分析仪对33例稳定型心绞痛患者、38例不稳定型心绞痛患者、36例急性心肌梗死患者和35例正常健康体检者的血清hs-CRP进行测定分析。结果各组血清hs-CRP含量分别为:正常对照组(3.89±2.57)mg/L,稳定型心绞痛组(7.58±2.72)mg/L,不稳定型心绞痛组(13.39±3.13)mg/L,急性心肌梗死组(18.27±5.81)mg/L。以上结果表明,稳定型心绞痛组、不稳定型心绞痛组和急性心肌梗死组的hs-CRP含量均显著高于正常对照组(P<0.01),随着冠心病严重程度的加重,由稳定型心绞痛到不稳定型心绞痛再到急性心肌梗死,hs-CRP含量也在依次增高,两者呈正相关。结论冠心病患者血清hs-CRP浓度比正常人明显升高,hs-CRP水平高低可反映冠心病的病变程度。
Objective To investigate the relationship between hs-CRP and the severity of coronary heart disease. Methods Serum hs-CRP levels in 33 patients with stable angina, 38 patients with unstable angina, 36 patients with acute myocardial infarction and 35 healthy controls were measured by IMMAGE automated special protein analyzer. Results The serum levels of hs-CRP in each group were (3.89 ± 2.57) mg / L in normal control group, 7.58 ± 2.72 mg / L in stable angina pectoris group and 13.39 ± 3.13 mg / L in unstable angina pectoris group, Acute myocardial infarction group (18.27 ± 5.81) mg / L. The above results showed that hs-CRP levels in stable angina group, unstable angina pectoris group and acute myocardial infarction group were significantly higher than those in normal control group (P <0.01). With the severity of coronary heart disease, To unstable angina and then to acute myocardial infarction, hs-CRP levels also increased, the two were positively correlated. Conclusion Serum hs-CRP levels in patients with coronary heart disease were significantly higher than those in normal subjects. The level of hs-CRP may reflect the severity of coronary heart disease.