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目的探究米索前列醇治疗产后出血的疗效以及分析米索前列醇治疗产后出血的药理作用。方法选取本院近年收治的产后出血产妇288例,随机分为4组,3组实验组,1组对照组,每组72例,对照组给予缩宫素治疗,对照组给予米索前列醇联合缩宫素治疗;观察产妇产后24 h的出血状况,以及用药后对比4组的治疗效果和不良反应。结果实验组的产妇产后2 h出血量(145.22±19.34)m L和产后2~24 h产后出血量(191.52±24.65)m L均显著低于对照组产妇产后2 h出血量(256.31±23.11)m L和产后2~24 h出血量(307.69±32.77)m L,差异有统计学意义(P<0.05);3个实验组的产妇产后2 h和2~24 h的出血量差异均无统计学意义(P>0.05);均无不良反应。结论米索前列醇对于产妇产后出血具有显著的临床疗效,米索前列醇不同的给药途径不存在显著性疗效差异。
Objective To investigate the curative effect of misoprostol on postpartum hemorrhage and to analyze the pharmacological effects of misoprostol on postpartum hemorrhage. Methods 288 cases of postpartum hemorrhage maternity admitted in our hospital in recent years were randomly divided into 4 groups, 3 experimental groups and 1 control group, with 72 cases in each group. The control group was treated with oxytocin. The control group was given misoprostol combined Oxytocin treatment; Obstetrics and Gynecology observation of bleeding after 24 hours of postpartum, and after treatment compared with the 4 groups of treatment and adverse reactions. Results The postpartum hemorrhage (145.22 ± 19.34) m L and postpartum postpartum 2 ~ 24 h postpartum (191.52 ± 24.65) m L were significantly lower in the experimental group than those in the control group at 256 h after delivery (256.31 ± 23.11) (P <0.05). There was no statistical difference in the amount of bleeding between the two experimental groups at 2 h and 2 ~ 24 h after delivery Significance (P> 0.05); No adverse reactions. Conclusion Misoprostol has a significant clinical effect on postpartum hemorrhage. There is no significant difference in the different routes of administration of misoprostol.