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肝脏病患者的用药须格外谨慎,因为这种情况下的药物作用常难以预料。肝细胞微粒体的酶系统是许多药物代谢的场所,但现尚缺少确实证据说明肝功能失调一定伴有药物代谢障碍。许多研究证明,肝硬变患者,某些药物如保泰松、乙酰水杨酸、安替匹林及氯丙嗪的血浆清除率正常;但甲苯磺丁脲(Tolbutamide)及硫喷妥钠的血浆清除率的研究结果则有矛盾,正常及降低的报告都有。患肝病致肝细胞减少者,药物代谢率仍可正常。因同时用其它药物刺激了留下来的肝细胞的微粒体酶类,使其活性升高。这种通过
Hypertensive patients should be treated with caution because the effects of drugs in this setting are often unpredictable. The enzyme system of hepatocyte microsomes is a site of many drug metabolism, but there is no conclusive evidence that liver dysfunction must be accompanied by drug-induced metabolic disorders. Many studies have shown that patients with cirrhosis, some drugs such as phenylbutazone, acetylsalicylic acid, anti-aspirin and chlorpromazine plasma clearance rate; but Tolbutamide (Tolbutamide) and thiopental sodium There are contradictory findings in plasma clearance studies, both normal and reported reductions. Liver disease caused by liver cell loss, drug metabolism rate can still be normal. At the same time with other drugs to stimulate the remaining microsomal enzymes of liver cells, so that its activity. This passed