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目的探讨新疆哈萨克族患者食管鳞状细胞癌中基因ARRB2 mRNA的表达情况及其与临床病理特征之间的关系。方法采用反转录-聚合酶链反应(RT-PCR)技术检测ARRB2基因在40例哈萨克族食管癌患者组织及其对应的远端无癌组织中的表达。结果 ARRB2基因在癌组织和远端无癌组织中的表达阳性率分别为62.5%,60.0%,差异无统计学意义(P>0.05)。ARRB2的表达与组织分化、TNM分期有关(P<0.05)。T内参/N内参≤0.5阳性表达差异率为42.5%(17例),T内参/N内参≥2阳性表达差异率为25.0%(10例)。结论新疆哈萨克族食管癌患者肿瘤组织ARRB2阳性表达率与组织分化、TNM分期有关。
Objective To investigate the expression of ARRB2 mRNA in esophageal squamous cell carcinoma and its relationship with clinicopathological features in Xinjiang Kazakh patients. Methods Reverse transcription-polymerase chain reaction (RT-PCR) was used to detect the expression of ARRB2 gene in 40 cases of Kazakh esophageal cancer tissues and their corresponding distal non-cancer tissues. Results The positive rate of ARRB2 gene expression in cancer tissues and distal non-cancer tissues was 62.5% and 60.0%, respectively. There was no significant difference (P>0.05). ARRB2 expression was related to histological differentiation and TNM stage (P<0.05). The difference in positive expression of T internal reference/N internal reference ≤0.5 was 42.5% (17 cases), and the differential expression rate of T internal reference/N internal reference ≥ 2 was 25.0% (10 cases). Conclusion The positive rate of ARRB2 in Kazakh patients with esophageal cancer in Xinjiang is related to histological differentiation and TNM staging.