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尾型同源框转录因子2(CDX2)是一种新发现的特异性转录因子,对正常和肿瘤性的肠上皮有相对特异性和敏感性,可引起肠上皮的分化,对其表型的维持也有重要作用。CDX2的表达对消化道肿瘤及癌前疾病和病变有良好的指示作用,综述CDX2与结肠癌及结肠息肉腺瘤之间的关系,CDX2在胃黏膜肠上皮化生、胃癌组织中的表达及其意义,CDX2的表达对Barrett食管早期诊断的价值等问题。
Tail-type homeobox transcription factor 2 (CDX2) is a newly discovered specific transcription factor, which has relative specificity and sensitivity to normal and tumorous intestinal epithelium, which can cause intestinal epithelial differentiation. Maintenance also plays an important role. The expression of CDX2 is a good indicator of gastrointestinal cancer and precancerous diseases and lesions. The relationship between CDX2 and colon and colon polyps adenoma, the expression of CDX2 in gastric mucosa intestinal metaplasia, gastric cancer tissue and its Significance, CDX2 expression on the early diagnosis of Barrett’s esophagus value and other issues.