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作者报道3例及其他作者报告的2例确诊为获得性大疱性表皮松解症(EBA)之后发生SLE的病例,并检查了另外15例无SLE临床表现的EBA患者的血清狼疮相关抗体.结果提示SLE和EBA之间有明显的关系.在观察和检查的20例确诊为EBA的病例中,9例有狼疮相关抗体,其中5例在EBA确诊后出现SLE的临床表现和自身免疫血清学特征(抗dsDNA抗体、循环抗U1RNP抗体和ANA的阳性率均为100%,抗Ro/SSA抗体为20%;抗Sm抗体为20%),1例在诊断为EBA时即有U1RNP抗体,5例在SLE发病时均出现这种抗体.5例伴有SLE的EBA病人最终均出现了抗
The authors reported two cases of SLE developed after confirmed EUS in three and other authors and examined serum lupus-related antibodies in 15 additional EBA patients without SLE. The results suggest that there is a clear relationship between SLE and EBA.Of the 20 cases diagnosed as EBA observed and examined, 9 cases had lupus-related antibodies, of which 5 cases showed clinical manifestations of SLE and autoimmune serology (Anti-dsDNA antibody, circulating anti-U1RNP antibody and ANA positive rate were 100%, anti-Ro / SSA antibody was 20%; anti-Sm antibody was 20%), 1 case at the time of diagnosis of EBA U1RNP antibody, 5 In the case of SLE onset of this antibody are present in all.5 cases of EBA patients with SLE eventually appeared in the anti-