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目的:探讨应用结合雌激素乳膏对围绝经期高血压Ⅲ级妇女生活质量的影响。方法:选取2012年5月~2013年5月间在新疆医科大学第二附属医院进行治疗的围绝经期高血压Ⅲ级患者72例,按随机数字表法将其平均分为观察组与对照组,每组各36例。对照组患者行高血压常规治疗;观察组患者在此基础上加用结合雌激素乳膏进行治疗。治疗1个月后观察两组疗效,同时统计患者尿频、尿急、阴道干涩、性交困难、性交痛等泌尿生殖道萎缩症状,对两组患者生活质量进行对比分析。结果:观察组高血压治疗效果稍低于对照组,差异无统计学意义(P>0.05);观察组患者中出现泌尿生殖道萎缩症状32例(88.9%),对照组为19例(52.8%),观察组明显低于对照组,两组比较,差异有统计学意义(P<0.05)。结论:对围绝经期高血压Ⅲ级患者,应用结合雌激素乳膏进行辅助治疗,不仅会显著降低高血压的临床治疗效果,同时还能有效提升妇女的生活质量,值得推广应用。
Objective: To explore the effect of combined estrogen cream on the quality of life of grade Ⅲ women with perimenopausal hypertension. Methods: Seventy-two patients with peri-menopausal hypertention grade Ⅲ who were treated in the Second Affiliated Hospital of Xinjiang Medical University from May 2012 to May 2013 were randomly divided into observation group and control group , 36 cases in each group. Patients in the control group underwent conventional treatment of hypertension; on the basis of this, patients in the observation group were treated with estrogen cream. One month after treatment, the curative effect of both groups was observed. At the same time, the urinary frequency, urinary urgency, vaginal dryness, difficulty in sexual intercourse and pain of genitourinary tract were observed. The quality of life of the two groups were compared. Results: In the observation group, the treatment effect of hypertension was slightly lower than that of the control group (P> 0.05). In the observation group, 32 cases (88.9%) had urogenital atrophy and 19 cases (52.8% ), The observation group was significantly lower than the control group, the difference between the two groups was statistically significant (P <0.05). Conclusion: The adjuvant therapy combined with estrogen cream for stage Ⅲ patients with perimenopausal hypertension not only can significantly reduce the clinical effect of hypertension, but also effectively improve the quality of life of women, which is worth popularizing and applying.