蜱抗原诱导的宿主免疫力的研究

• 作 者: 刘志刚 宋杰益 彭卫东 崔晓民 熊国强 胡细庚 胡有长 罗军
• 机 构: 江西医学院寄生虫学教研室,江西医学院寄生虫学教研室,江西医学院寄生虫学教研室,江西医学院寄生虫学教研室,南昌市西湖区卫生防疫站,南昌市西湖区卫生防疫站,江西医学院微生物学教研室,江西医学院微生物学教研
• 出 处: 江西医学院学报
• 发表日期: 1992年03期
• 关键词: 宿主免疫 免疫反应 实验 对比研究 蟀兔 细胞免疫 二棘血蜱 刺激指数

报道在实验室控制条件下,用二棘血蜱叮咬家兔诱导其产生获得性免疫力。结果表示:叮咬组家兔经 ELISA 法测定其体内抗体(OD 值0.54),较对照组(OD 值0.09)有显著升高(P<0.01),叮咬家兔后其~3H—TdR 淋巴细胞转化试验的 PHA 刺激指数为67.11±35.16,较对照组15.49±14.53.有显著升高(P<0.01);另外,两组的皮肤试验也有极显著差异。(P<0.001),表明家兔对二棘血蜱叮咬所产生的获得性免疫力不仅与宿主的体液免疫有关,同时也与宿主的细胞免疫有关。

It was reported that rabbits were bitten by B. spinosus to induce adaptive immunity in laboratory-controlled conditions. The results showed that the rabbits in the bite group had significantly higher antibody (OD 0.54) than the control group (OD 0.09) by ELISA (P <0.01), and the ~ 3H-TdR lymphocyte transformation The PHA stimulation index was 67.11 ± 35.16, which was significantly higher than that of the control group (15.49 ± 14.53) (P <0.01). In addition, the skin test of the two groups was also significantly different. (P <0.001), indicating that the acquired immune response to B. bilineata ticks was not only related to the humoral immunity of the host, but also to the cellular immunity of the host.