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AIM:To evaluate the value of positron emission tomography(PET)/computerized tomography(CT)in surveillance of colorectal cancer(CRC)patients with different carcinoembryonic antigen(CEA)concentrations.METHODS:One hundred and six postoperative CRC patients who had suspected recurrence or metastasis and received fluorodeoxyglucose(FDG)PET/CT within one week were included in this study.The final diagnosis was confirmed by histological examination or clinicalfollow-up over at least six months.RESULTS:The sensitivity,specificity,and accuracy of FDG PET/CT were 95.2%,82.6%,and 92.5%,and94.8%,81.4%and 92.8%,respectively,in the caseand lesion-based analyses.The sensitivity and accuracy of FDG PET/CT significantly differed from CT in both analyses(χ2=8.186,P=0.004;χ2=6.201,P=0.013;χ2=13.445,P=0.000;χ2=11.194,P=0.001).In the lesion-based analysis,the sensitivity,specificity,and accuracy of FDG PET/CT in the abnormal CEA group were97.8%,82.6%,and 95.6%,compared with 81.3%,80%,and 80.6%for patients with normal CEA levels.In case-based analysis,the sensitivity,specificity,and accuracy of FDG PET/CT were 97.2%,77.8%,and 95%in abnormal CEA group.Only in lesion-based analysis,the sensitivity and accuracy of FDG PET/CT in the abnormal CEA group were significantly superior to those in the normal CEA group(χ2=6.432,P=0.011;χ2=7.837,P=0.005).FDG PET/CT changed the management in 45.8%of patients with positive scans.CONCLUSION:FDG PET/CT showed superior diagnostic value and is an advisable option in surveillance of postoperative CRC patients with a vague diagnosis.
AIM: To evaluate the value of positron emission tomography (PET) / computerized tomography (CT) in surveillance of colorectal cancer (CRC) patients with different carcinoembryonic antigen (CEA) concentrations. METHODS: One hundred and six postoperative CRC patients who had underlying recurrence or metastasis and received fluorodeoxyglucose (FDG) PET / CT within one week were included in this study. The final diagnosis was confirmed by histological examination or clinicalfollow-up over at least six months .RESULTS: The sensitivity, specificity, and accuracy of FDG PET / CT were 95.2%, 82.6%, and 92.5%, and 94.8%, 81.4% and 92.8%, respectively, in the case and lesion-based analyzes. The sensitivity and accuracy of FDG PET / CT highly differed from CT in both analyzes (χ2 = 8.186, P = 0.004; χ2 = 6.201, P = 0.013; χ2 = 13.445, P = 0.000; χ2 = 11.194, P = 0.001) .In the lesion-based analysis, the sensitivity, specificity, and accuracy of FDG PET / CT in the abnormal CEA group were 97.8%, 82.6%, and 95.6%, compared with 81.3%, 80%, and 80.6% for patie nts with normal CEA levels. In case-based analysis, the sensitivity, specificity, and accuracy of FDG PET / CT were 97.2%, 77.8%, and 95% in abnormal CEA group. Notly in lesion-based analysis, the sensitivity and accuracy of FDG PET / CT in the abnormal CEA group were significantly superior to those in the normal CEA group (χ2 = 6.432, P = 0.011; χ2 = 7.837, P = 0.005) with positive scans. CONCLUSION: FDG PET / CT showed superior diagnostic value and is an advisable option in surveillance of postoperative CRC patients with a vague diagnosis.