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目的 了解合肥市健康人群流行性脑脊髓膜炎(简称流脑)带菌和免疫水平状况,为制定有效的防控措施提供依据.方法 按分层整群抽样方法,在合肥市范围内采集6个年龄组健康人群咽拭子及静脉血分别进行脑膜炎奈瑟菌(N meningitidis,Nm)培养及A、C、Y、W135型流脑血清抗体检测.结果 共采集1 093名健康者咽拭子标本,总带菌率为2.10％ (23/1 093).其中A群带菌率为0.27％,B群带菌率为0.37％,C群带菌率为1.37％,W135群带菌率为0.09％,其它菌群未检出;共采集1 093名健康者血清标本,A群阳性率为87.83％,C群阳性率为91.22％,Y群阳性率为54.25％,W135群阳性率为40.26％.结论 目前合肥市健康人群流脑W135群、Y群抗体阳性率较低,建议适龄儿童在3岁和6岁接种A+C+Y+W135群四价流脑疫苗;要警惕B群流脑病例,做好B群流脑实验室检测和密切接触者的药物预防作用.“,”Objective To understand the immune level against epidemic cerebrospinal memngitis and career status of neissena meningitidis in healthy population,provide scientific basis for prevention and control.Methods According to the stratified cluster sampling method,6 healthy age groups of throat swabs and venous blood were collected for Neisseria meningitidis in Hefei,A,C,culture and detection of Y and W135 type serum antibody of ecm.Results Among 1 093 subjects,Nm was positive in 23 throat swabs,the carrier rate was 2.10％.And the carrier rate of Nm serogroup A,B,C,W135 were 0.27％,0.37％,1.37％,0.09％ respectively.The serumantibody positive rate in Nm serogroup A,B,C,W135 were 87.83％,91.22％,54.25％,40.26％ respectively.Conclusion Group W135 and group Y antibody positive rate is low,the proposed school-age children at the age of 3 and 6 year old group A + C + Y + W135 quadrivalent meningitis vaccine inoculation;to guard against serogroup B cases,preventive effects of drugs on laboratory testing and close contacts.