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目的：观察尿激酶（ＵＫ）静脉溶栓治疗急性脑梗死的疗效及安全性。方法：急性脑梗死患者５０例予ＵＫ１５×１０５Ｕ加入５％葡萄糖１００ｍｌ中３０分钟内静滴完，同时口服阿斯匹林０．３ｇ／ｄ（３日后改为７５ｍｇ／ｄ），溶栓开始１２小时后皮下注射肝素７５００Ｕ（之后每１２小时１次，连用３日）。于注射２４小时后判定疗效。结果：５０例患者经ＵＫ静脉溶栓治疗总有效率为９０．０％，其中４２例发病６小时内溶栓者及８例发病６小时～１２小时溶栓者总有效率分别为９２．９％和７５．０％，二者比较无显著性差异（ｕ＝１．５５，Ｐ＞０．０５）；但其基本痊愈率差异显著（ｕ＝２．２６，Ｐ＜０．０５）。老年患者（≥６０岁）总有效率及基本痊愈率均明显低于＜６０岁患者（ｕ＝２．０１，Ｐ＜０．０５及ｕ＝２．００，Ｐ＜０．０５）。本组患者ＵＫ静脉溶栓后脑出血（均为梗死灶内斑片状出血）、脑水肿及皮肤粘膜轻度出血发生率分别为６．０％、６．０％和４．０％，均未出现过敏反应、再梗死及死亡。结论：ＵＫ静脉溶栓治疗急性脑梗死效果可靠、安全，并且溶栓开始至发病时间越短、年龄越小，其溶栓效果越好
Objective: To observe the efficacy and safety of urokinase (UK) intravenous thrombolysis in the treatment of acute cerebral infarction. Methods: Fifty patients with acute cerebral infarction were treated with intravenous infusion of aspirin (0.3g / d) (75mg / d after 3 days) and intravenous infusion of aspirin (50mg / d) After hours of subcutaneous injection of heparin 7500U (after every 12 hours 1, once every 3 days). After injection for 24 hours to determine the efficacy. Results: The total effective rate of 50 patients treated by UK intravenous thrombolysis was 90.0%. The total effective rate of thrombolytic therapy in 42 patients within 6 hours and 8 patients with thrombolysis in 6 hours to 12 hours were 92.9 % And 75.0% respectively. There was no significant difference between the two groups (u = 1.55, P> 0.05). However, the difference between the two groups was significant (u = 2.26, P <0.05). The total effective rate and the basic cure rate in elderly patients (≥60 years old) were significantly lower than those in patients <60 years old (u = 2.01, P <0.05 and u = 2.00, P <0.05). This group of patients with UK after intravenous thrombolysis cerebral hemorrhage (both infarction patchy hemorrhage), brain edema and skin mucosal mild bleeding were 6.0%, 6.0% and 4.0%, respectively, none An allergic reaction, then infarction and death. Conclusion: UK intravenous thrombolytic therapy for acute cerebral infarction is reliable and safe, and the shorter the onset of thrombolysis to onset, the younger, the better the thrombolytic effect