论文部分内容阅读
目的探讨血液中N末端B型利钠肽原(NT-pro BNP)对非ST段抬高型急性冠状动脉综合征(NSTE-ACS)危险分层的价值。方法选取2012年1月~2013年12月间我科94例NSTE-ACS患者分为高危NSTE-ACS组52例(高危UAP22例,NSTEMI30例)和非高危NSTE-ACS组42例[低危UAP20例,中危UAP 22例];将具有胸痛症状且经冠状动脉CT造影(CCTA)证实为阴性的患者为对照组,共38例。入院后即刻采集静脉血同时检测NTpro BNP、高敏肌钙蛋白T(hs-c Tn T)浓度,比较各组间NT-pro BNP、hs-c Tn T浓度的变化,并分析其相关性。结果高危NSTE-ACS组NT-pro BNP、hs-c Tn T浓度均高于非高危NSTE-ACS组,差异有统计学意义(P<0.01),经Pearson直线相关分析,高危NSTE-ACS组NT-pro BNP浓度与hs-c Tn T浓度呈正相关(r=0.92,P<0.001);非高危NSTEACS组NT-pro BNP浓度与hs-c Tn T浓度亦呈正相关(r=0.83,P<0.001)。结论 NT-pro BNP是心肌缺血损伤的可靠指标,可作为NSTE-ACS危险分层的依据。
Objective To investigate the value of blood N-terminal pro-brain natriuretic peptide (NT-pro BNP) in risk stratification of non-ST segment elevation acute coronary syndrome (NSTE-ACS). Methods From January 2012 to December 2013, 94 patients with NSTE-ACS in our department were divided into high risk NSTE-ACS group (52 cases), 22 cases of high risk UAP (NSTEMI30) and 42 cases of non-high risk NSTE-ACS Cases, 22 cases of moderate-risk UAP]; the patients with chest pain symptoms confirmed by CTTA were negative as control group, a total of 38 cases. Venous blood samples were taken immediately after admission, and the concentrations of NTpro BNP and hs-c Tn T were detected. The concentrations of NT-proBNP and hs-cTn T in each group were compared and analyzed. Results The concentrations of NT-pro BNP and hs-c Tn T in high-risk NSTE-ACS group were significantly higher than those in non-high-risk NSTE-ACS group (P <0.01). The Pearson’s linear correlation analysis showed that NT- -pro BNP was positively correlated with the concentration of hs-c Tn T (r = 0.92, P <0.001). The NT-pro BNP concentration was also positively correlated with the concentration of hs-c Tn T in non-high risk NSTE ACS group ). Conclusion NT-pro BNP is a reliable indicator of myocardial ischemic injury and can be used as a basis for risk stratification of NSTE-ACS.