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目的优化去卷积法肺癌首过期CT灌注(CTP)检查的时间分辨率(TR)。资料与方法经证实的60例肺癌患者行首过期CTP扫描。通过剔除TR=0.5s序列部分图像,得到TR分别为1～4s的6组数据。对CTP参数行随机区组的协方差分析后行两两比较。结果不同TR组的血容量(BV)与表面通透性(PS)值无统计学差异,血流量(BF)与对比剂的平均通过时间(MTT)值有统计学差异(P均<0.001)。与TR=0.5s组比较,TR=1、1.5、2s组的BF及MTT值无统计学差异;TR=2.5、3及4s组的BF及MTT值有统计学差异(P均<0.05)。结论 TR应≤2s,以保证去卷积法肺癌首过期CTP准确性;采用稍低TR(1.5s或2s),可降低患者X线辐射剂量。
Objective To optimize the time resolution (TR) of deconvolution-based first-phase CT perfusion imaging (CTP) in lung cancer. Materials and Methods 60 cases of lung cancer confirmed by the first line of expired CTP scan. By removing part of the TR = 0.5s sequence images, 6 sets of data with TRs of 1 to 4 s respectively were obtained. Covariance analysis of randomized block CTP parameters row after row comparison. Results There was no significant difference in the values of BV and PS among different TR groups. There was a significant difference (P <0.001) between mean flow time (MTT) and blood flow (BF) . Compared with TR = 0.5s group, there was no significant difference of BF and MTT between TR = 1, 1.5 and 2s group; BF and MTT values of TR = 2.5, 3 and 4s group were statistically different (all P <0.05). Conclusions TR should be ≤2s, to ensure the accuracy of deconvolution in the first phase of lung cancer CTP. Using a lower TR (1.5s or 2s) can reduce the dose of X-ray.