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目的探讨血管内皮生长因子(VEGF)和基质金属蛋白酶-9(MMP-9)在胃癌中的表达及其与胃癌转移、预后的相关性。方法将50例胃癌患者根据组织学分级、浸润深度、有无淋巴结转移及TNM分期分别分组,另选同期14例慢性浅表性胃炎患者作为对照组,应用免疫组化SABC法检测VEGF、MMP-9的表达,并对VEGF和MMP-9表达与胃癌浸润转移的关系进行分析。结果胃癌组MMP-9和VEGF的水平均显著高于对照组(均P<0.05)。MMP-9和VEGF表达在胃癌分化程度、浸润深度、淋巴结转移、TNM分期及远处转移的不同分组中均有显著差异(P<0.05)。结论胃癌患者VEGF和MMP-9表达显著升高,并与肿瘤分期及远处转移有关,其过度表达可作为评估胃癌浸润转移和预后不良的参考指标。
Objective To investigate the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in gastric cancer and their relationship with metastasis and prognosis of gastric cancer. Methods Fifty patients with gastric cancer were divided into groups according to histological grade, depth of invasion, lymph node metastasis and TNM staging. Another 14 patients with chronic superficial gastritis were selected as control group. Immunohistochemical SABC method was used to detect the expressions of VEGF and MMP- 9 expression, and VEGF and MMP-9 expression and invasion and metastasis of gastric cancer were analyzed. Results The levels of MMP-9 and VEGF in gastric cancer group were significantly higher than those in control group (all P <0.05). The expression of MMP-9 and VEGF were significantly different in different groups (P <0.05) in differentiation, depth of invasion, lymph node metastasis, TNM staging and distant metastasis. Conclusion The expression of VEGF and MMP-9 in patients with gastric cancer is significantly increased, which is correlated with tumor stage and distant metastasis. The overexpression of VEGF and MMP-9 can be used as a reference index to evaluate the invasion and metastasis of gastric cancer and poor prognosis.