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本文介绍了以核糖体为靶点的几种重要抗生素的作用机制,在此基础上对近几年来出现的此类药物研究的新方法新思路进行了综述。远程交互作用网络及诱导-契合机制的发现、抗生素抑制蛋白质合成的新靶点的发掘、利用计算机辅助药物设计技术及其他物理化学分析方法如分子建模技术、计算机动态模拟技术、分子对接技术、X-ray衍射技术进行新型抗生素研究,使我们对于药物与核糖体的结合方式及结合位点有了更加深入的了解,为科研人员对新型抗生素的开发和研究带来了无限的希望。
This paper introduces the mechanism of action of several important antibiotics targeting ribosomes, and reviews the new ideas and methods of such drug research in recent years. The discovery of remote interaction networks and induction-fit mechanisms, the discovery of novel targets for antibiotic inhibition of protein synthesis, the use of computer-aided drug design techniques and other physicochemical analysis methods such as molecular modeling techniques, computer simulation techniques, molecular docking techniques, X-ray diffraction technology for new antibiotic research, so that we have a more in-depth understanding of the drug and ribosome binding methods and binding sites for researchers on the development and research of new antibiotics has brought unlimited hope.