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目的:考察两种卡铂注射液与输液的配伍稳定性。方法:将两种卡铂注射液分别使用0.9%氯化钠、5%葡萄糖溶液稀释,分别在25℃和42℃下于0,2,4,6,8,12,24 h时观察配伍液的外观变化,测定其pH值,采用高效液相色谱法测定配伍液中卡铂的相对百分含量。结果:在上述条件下,配伍液在24 h内外观和pH值均无明显变化;齐鲁卡铂各时间点、各配伍液中卡铂的相对百分含量为94.55%~100.64%,RSD<2%;施贵宝卡铂各时间点、各配伍液中卡铂的相对百分含量为91.55%~100.37%,RSD<3%。结论:两种卡铂注射液与0.9%氯化钠注射液、5%葡萄糖注射液配伍后,在25℃和42℃条件下,24 h内稳定,在葡萄糖中稳定性更好。
Objective: To investigate the compatibility of two carboplatin injection and infusion stability. Methods: The two carboplatin injection were diluted with 0.9% sodium chloride, 5% glucose solution, respectively, at 25 ℃ and 42 ℃ at 0,2,4,6,8,12,24 h when observed compatibility of the solution The appearance of change, determination of its pH, high performance liquid chromatography determination of the relative percentage of carboplatin in the compatibility. Results: Under the above conditions, there was no significant change in the appearance and pH value of the compatibility solution within 24 h. The relative percentage of carboplatin in each compatibility solution was 94.55% ~ 100.64% at each time point of Qiluka Platinum, RSD <2 %. The relative percentages of carboplatin in all compatibility solutions were 91.55% ~ 100.37% and RSD <3% at all time points. CONCLUSION: The two carboplatin injections are compatible with 0.9% sodium chloride injection and 5% glucose injection and are stable within 24 h at 25 ℃ and 42 ℃, with better stability in glucose.