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青霉素是五大抗生素之一;它在医疗上的广泛用途,是人所共知的。由于青霉素对于人民保健事业的重大作用,在我国的第一个五年计划中,亦列为主要生产品之一,并以巨大的规模进行生产。虽然青霉素极其重要,但是目前,青霉素的生产在任何国家还仍旧是通过生物合成的途径来实现的。青霉素的人工合成方法,曾经引起了许多人的兴趣,出现了庞大数量的有关论文。在青霉素合成化学的领域中,可以找到资本主义国家中,许多卓越化学家的足迹,如鲁宾孙(R.Robinson),狄·芬里奥(V.du Vignea-ud)等人。但是所有这些企图,都没有满意的结果。例如,以狄·芬里奥为首所提供的青霉素G的合成,产
Penicillin is one of the top five antibiotics; its widespread use in medicine is well known. Since penicillin plays a major role in people’s health care, it is also listed as one of the major products in our country’s first five-year plan and is produced on a huge scale. Although penicillin is extremely important, at present, the production of penicillin is still through biosynthesis in any country. The synthetic method of penicillin, once aroused the interest of many people, appeared a large number of related papers. In the field of penicillin synthetic chemistry, one can find footprints of many prominent chemists in capitalist countries, such as R. Robinson and V. du Vignea-ud et al. However, all these attempts have not been satisfactory results. For example, the synthesis of penicillin G provided by Di Finlio