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本文应用双抗体标记和流式细胞分析技术，对５５例颌面部鳞状上皮源性良恶性肿瘤及正常组织进行ＤＮＡ指数、增殖指数、Ｓ期细胞比例及ｐ２１蛋白的表达进行了定量分析。结果：正常皮肤和乳头状瘤均为二倍体，鳞癌异倍体率为６０％，并随病理分级增高而增高；增殖指数和Ｓ期细胞所占的百分比在这三种组织中均有显著性差异；正常组织ｐ２１蛋白的表达为阴性；乳头状瘤ｐ２１蛋白阳性表达率为３０％；鳞癌ｐ２１阳性表达率为７０％；鳞癌ｐ２１蛋白的阳性表达率和表达强度均显著高于其它两种组织。结论认为ｐ２１蛋白在良性肿瘤中也有部分阳性表达。但表达率显著低于恶性肿瘤，ｐ２１蛋白的检测在用于对易恶变疾病的监测方面的作用要大于用在对恶性肿瘤恶性度的判定方面
In this paper, the double-antibody marker and flow cytometric analysis techniques were used to quantitatively analyze the DNA index, proliferation index, S-phase cell ratio and p21 protein expression in 55 cases of squamous cell-derived benign and malignant tumors and normal tissues. Results: Normal skin and papillomas were diploid and the squamous cell carcinoma was 60% aneuploid and increased with pathological grade. The percentage of proliferative index and S-phase cells were in all three tissues. Significant difference; normal tissue p21 protein expression was negative; papillary tumor p21 protein positive expression rate was 30%; squamous cell carcinoma p21 positive rate was 70%; squamous cell carcinoma p21 protein positive expression rate and expression intensity were significantly higher than The other two organizations. It is concluded that p21 protein is also partially expressed in benign tumors. However, the expression rate was significantly lower than that of malignant tumors, and the detection of p21 protein was more effective in the monitoring of vulnerable diseases than in the determination of malignancy of malignant tumors.