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目的探讨替罗非班对急性心肌梗死患者急诊经皮冠状动脉介入术后心肌灌注的影响。方法将我院收治的68例急性心肌梗死患者(均为ST段抬高)作为研究对象,随机分为观察组和对照组。两组患者均口服阿司匹林和氯吡格雷。对照组于PCI术前注射肝素,观察组于动脉穿刺前或者造影结束时进替罗非班静脉注射,维持24h静脉滴注,再注射肝素。比较两组患者的心肌呈色分级和ST段回落百分比。结果术后观察组Ⅲ级新机成色占比为70.59%,显著高于对照组38.24%;观察组sum STR为61.3±25.8,对照组为42.7±36.2;sum STR≥70%者观察组占比61.76%,显著高于对照组29.41%;两组术后左心室射血分数分别是55.6±4.8和50.7±6.9。两组数据对比,差异显著,P<0.05,具有统计学意义。结论替罗非班有助于改善急诊PCI术后心肌灌注指标,帮助改善心功能,利于患者术后恢复。
Objective To investigate the effect of tirofiban on myocardial perfusion after emergency percutaneous coronary intervention in patients with acute myocardial infarction. Methods A total of 68 patients with acute myocardial infarction (all ST-segment elevation) admitted to our hospital were randomly divided into observation group and control group. Both groups were given aspirin and clopidogrel orally. The control group was injected with heparin before PCI, and the observation group was injected with tirofiban intravenously before arterial puncture or at the end of angiography. The myocardial grading and ST-segment fall percentage of the two groups were compared. Results The grade Ⅲ new machine postoperative color imaging accounted for 70.59%, significantly higher than the control group 38.24%; the observation group sum STR 61.3 ± 25.8, the control group was 42.7 ± 36.2; sum STR ≥ 70% of the observation group accounted for 61.76%, significantly higher than the control group 29.41%; left ventricular ejection fraction after surgery were 55.6 ± 4.8 and 50.7 ± 6.9. There was significant difference between the two groups of data, P <0.05, with statistical significance. Conclusion Tirofiban helps to improve myocardial perfusion parameters after emergency PCI, and helps to improve cardiac function and facilitate postoperative recovery.