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流行病学和生化数据表明,铝参与早老性痴呆病的发生。然而至今尚不能证实其明显的因果关系。在一次研究中,给痴呆病人肌注去铁胺(deferoxamine),疗效很好。将48例可能患早老性痴呆的病人分成三组,治疗2年:第一组肌注去铁胺,一日2次,每次500mg,连续2周;随后一日2次,每次125mg。周末停药,以避免铁的过度丢失。第二组口服安慰剂(500mg卵磷脂)。第三组没有治疗。在家里用录像监视治疗过程,对半年内
Epidemiological and biochemical data suggest that aluminum is involved in the development of Alzheimer’s disease. However, its obvious causal relationship can not be confirmed yet. In one study, deferoxamine was administered intramuscularly to patients with dementia and was effective. Forty-eight patients with Alzheimer’s disease were divided into three groups and treated for 2 years: Group 1 received deferoxamine twice a day for 500 mg twice daily for 2 weeks; followed by 125 mg twice daily on the following day. Weekend withdrawal, in order to avoid excessive loss of iron. The second group was given placebo (500 mg lecithin). The third group did not have treatment. At home with video surveillance treatment process, within six months