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目的比较不同性别对高血糖/糖尿病人群新发临床终点事件的影响。方法本研究采用前瞻性队列研究方法,以参加2006年7月—2007年10月健康查体的101 510名开滦集团职工中空腹血糖≥7.0mmol/L或<7.0mmol/L但已确诊为糖尿病,正在使用降糖药物的8 302例高血糖/糖尿病者作为观察队列,随访38~53(48.01±3.14)个月,随访期间每半年收集一次新发心脑血管事件情况。分析性别差异对高血糖/糖尿病人群新发心脑血管事件的影响。结果 1与男性患者相比,女性患者体质量指数(MBI)、TC、HDL较高,而LDL、DBP较低,差异有统计学意义(P<0.05),且女性患者吸烟人数明显少于男性患者(P<0.05)。2随访期间内共发生心脑血管事件374例(有发生两次或以上事件者,统计总心脑血管事件时只记为1次,以最先发生终点事件的时间和事件为结局)。其中男性组发生总事件322例(4.72%)、脑梗死200例(2.93%),全因死亡250例(3.66%);女性组发生总事件52例(3.52%)、脑梗死29例(1.96%),全因死亡34例(2.30%),差异有统计学意义(P<0.05)。3多变量Cox比例风险回归分析表明,性别的相对危险最高,相对于女性组,男性组总事件、脑梗死及全因死亡RR值分别增加1.35倍(95%CI:1.01~1.81,P<0.05)、1.52倍(95%CI:1.03~2.25,P<0.05)、1.64倍(95%CI:1.13~2.36,P<0.05)。结论男性糖尿病患者心脑终点事件的发生率高于女性患者。
Objective To compare the effects of different genders on new clinical endpoint in hyperglycemia / diabetes mellitus. Methods A prospective cohort study was conducted in 101 510 Kailuan Group workers who participated in the health checkup from July 2006 to October 2007 with fasting blood glucose ≥7.0 mmol / L or <7.0 mmol / L but were diagnosed as Diabetes, 8 302 hyperglycemia / diabetes patients using hypoglycemic drugs were included in the observation cohort. The follow-up was 38-53 (48.01 ± 3.14) months. New cardiovascular and cerebrovascular events were collected every six months during the follow-up period. Analysis of the impact of gender differences on new cardiovascular and cerebrovascular events in hyperglycemia / diabetic population. Results Compared with male patients, female patients had higher body mass index (MBI), TC, HDL, and lower LDL and DBP (P <0.05), and smoking in female patients was significantly less than that in men Patients (P <0.05). During the follow-up period, there were 374 cardiovascular and cerebrovascular events (there were two or more events, the total cardiovascular events were counted as only one, and the time and event of the first endpoint occurred. There were 322 cases (4.72%) in the male group, 200 cases (2.93%) in the cerebral infarction and 250 cases (3.66%) in the all-cause death group. There were 52 cases (3.52%) in the female group and 29 cases %), All causes of death in 34 cases (2.30%), the difference was statistically significant (P <0.05). 3 Multivariate Cox proportional hazards regression analysis showed that the relative risk of gender was the highest, relative to the female group, the total events, the total risk of cerebral infarction and all-cause mortality in the male group increased by 1.35 times (95% CI: 1.01-1.81, P <0.05 ), 1.52-fold (95% CI: 1.03-2.25, P <0.05), 1.64-fold (95% CI: 1.13-2.36, P <0.05). Conclusions The incidence of cardiac end point events in male patients with diabetes is higher than that in female patients.