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本文应用全细胞膜片箝技术在新鲜分离的大鼠背根神经节（DRG）神经元上研究缓激肽（BK）对γ-氨基丁酸（GABA）反应的调制作用。结果发现：在34个对GABA反应的细胞中有31个细胞对BK敏感。在对BK敏感并引起内向电流的27个细胞中预加BK，对GABA-激活电流具有明显的抑制作用，如10-6mol／L的BK可抑制GABA（10-4mol／L）激活电流30％。BK可将GABA量效曲线明显下移，并抑制其最大反应达1／3以上，而不改变其Kd值。结果提示：BK能非竞争性地抑制GABA反应。
In this study, the modulation of GABA on bradykinin (BK) in freshly isolated rat DRG neurons was studied using whole-cell patch clamp technique. As a result, it was found that 31 cells were sensitive to BK in 34 cells responding to GABA. Pre-adding BK to 27 cells that are sensitive to BK and induce an inward current significantly inhibits the GABA-activated current. For example, 10-6 mol / L of BK inhibits GABA (10-4 mol / L) activation current by 30% . BK can significantly down-shift the dose-response curve of GABA and inhibit its maximal response to more than 1/3 without changing its Kd value. The results suggest that BK can non-competitively inhibit GABA response.