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噻吗心安(Timolol)是一种β_1和β_2肾上腺素能受体非选择性阻滞剂,近年来被广泛使用于治疗开角型青光眼和其他各种类型的高眼压症。其作用原理似为噻吗心安与睫状突内特异细胞的β-肾上腺素能受体结合,阻滞了内源性儿茶酚胺,使环磷酸腺苷(CAMP)浓度和房水的形成不致增加,从而减少房水的生成量,并不影响房水的流出量。有人认为噻吗心安是近年来在青光眼药物治疗上一个突破性的进展,并被认为与1877年的毛果芸香硷和1954年的醋氮酰胺的问世有着同等的价值。但由于本药在临床上应用为时较短,国外眼科于1974年开始应用于治疗青光眼,在国内推广应用是在1981年以后国内生产本药开始。因此,人们对它还未充分认识,对此药的副作用了解也不够。为了更合理地应用此药,本文将近年文献报道此药的副作用综述
Timolol is a β 1 and β 2 adrenergic receptor non-selective blockers, in recent years has been widely used in the treatment of open angle glaucoma and other types of ocular hypertension. Its principle of action seems to be timolol and ciliary processes specific cells β-adrenergic receptor binding, blocking the endogenous catecholamines, cAMP concentration and aqueous humor formation did not increase, To reduce the formation of aqueous humor, does not affect the outflow of aqueous humor. Some people think that timolol is a breakthrough in the treatment of glaucoma medicine in recent years and is considered to have the same value with the advent of pilocarpine in 1877 and 1954 acetylamide. However, due to the clinical application of the drug for a short time, foreign ophthalmology began to be used in the treatment of glaucoma in 1974, in the country to promote the use of the domestic production of this medicine after 1981 began. Therefore, people are not yet fully aware of it and do not know enough about the side effects of this medicine. In order to more reasonable use of this medicine, this article in recent years reported the literature side effects of this drug review