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目的:探讨补体C1q肿瘤坏死因子相关蛋白1(C1q tumor necrosis factor-related protein 1,CTRP1)与冠状动脉粥样硬化性心脏病(冠心病)间的相关性。方法:根据冠状动脉(冠脉)造影结果提示冠脉管腔狭窄是否≥50%,将研究对象分为冠心病组(103例)和对照组(100例),采用酶联免疫吸附试验检测CTRP1、脂联素(adiponectin,APN)、肿瘤坏死因子α(tumor necrosis factor-α,TNF-α)、白细胞介素6((interleukin-6,IL-6)、IL-8、细胞间粘附分子1(intracellular adhesion molecule 1,ICAM-1)、血管细胞粘附分子1(vascular cell adhesion molecule-1,VCAM-1)和单核细胞趋化蛋白1(monocyte chemotactic protein-1,MCP-1)水平,结果应用SPSS 19.0软件进行统计分析。结果:冠心病组的血清CTRP1水平显著高于对照组[(16.68±12.10)ng/m L比(10.27±5.68)ng/m L],差异有统计学意义(P<0.001)。校正性别、年龄、空腹血糖、糖化血红蛋白(hemoglobin A1c,Hb A1c)后,冠心病组的血清CTRP1水平与Gensini积分呈正相关(r=0.279,P=0.015),而Gensini积分的四分位分组中,评分最高组的血清CTRP1水平显著高于其余3组[(23.45±18.87)ng/m L比(11.27±5.88)ng/m L、(15.15±9.12)ng/m L、(17.00±7.82)ng/m L],差异有统计学意义(P均<0.05)。在冠心病组中,经相关分析显示,校正性别、年龄、空腹血糖、Hb A1c后,CTRP1与TNF-α、IL-6、ICAM-1、MCP-1水平(r=0.260、0.448、0.362、0.287,P均<0.05)呈正相关。Logistic回归分析显示,空腹血糖(OR=1.740,95%CI为1.027~2.880,P<0.05)、Hb A1c(OR=2.714,95%CI为1.133~6.499,P<0.05)、IL-8(OR=1.041,95%CI为1.008~1.073,P<0.05)、CTRP1(OR=1.136,95%CI为1.060~1.218,P<0.05)水平升高,是冠心病发病的危险因素。结论:血清CTRP1水平在冠脉狭窄≥50%患者中显著升高,且与其冠脉病变严重程度呈正相关,提示血清CTRP1测定有可能成为临床冠脉病变评估的有效指标。
Objective: To investigate the relationship between C1q tumor necrosis factor-related protein 1 (CTRP1) and coronary atherosclerotic heart disease (CHD). Methods: According to coronary artery (coronary) angiography findings, whether coronary stenosis was ≥50%, the subjects were divided into coronary heart disease group (n = 103) and control group (n = 100). ELISA was used to detect CTRP1 , Adiponectin (APN), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin- 1, ICAM-1, VCAM-1 and monocyte chemotactic protein-1 (MCP-1) , And the results were analyzed by SPSS 19.0 software.Results: The level of serum CTRP1 in coronary heart disease group was significantly higher than that in the control group [(16.68 ± 12.10) ng / m L vs (10.27 ± 5.68) ng / m L] (P <0.001) .Serum CTRP1 level in coronary heart disease group was positively correlated with Gensini score (r = 0.279, P = 0.015) after adjusting gender, age, fasting blood glucose and hemoglobin A1c (Hb A1c) Among the four quartiles, the level of serum CTRP1 in the highest score group was significantly higher than that in the other three groups [(23.45 ± 18.87) ng / m L vs (27 ± 5.88) ng / m L, (17.00 ± 7.82) ng / m L, respectively, P <0.05) .In the CHD group, Correlation analysis showed that the levels of CTRP1, TNF-α, IL-6, ICAM-1 and MCP-1 were significantly lower than those before Hb A1c (r = 0.260,0.448,0.362,0.287, P <0.05) (OR = 1.740, 95% CI: 1.027-2.880, P <0.05), Hb A1c (OR = 2.714, 95% CI: 1.133-6.499, P <0.05) and IL- (OR = 1.041, 95% CI: 1.008-1.073, P <0.05), and CTRP1 (OR = 1.136, 95% CI: 1.060-1.218, P <0.05) was the risk factor for coronary heart disease. : Serum CTRP1 levels were significantly higher in patients with coronary stenosis ≥50% and positively correlated with the severity of coronary lesions, suggesting that serum CTRP1 may be an effective indicator for the evaluation of clinical coronary artery disease.