Development and validation of a GC-FID method for quantitative analysis of oleic acid and related fa

• 作 者: Honggen Zhang Zhenyu Wang Osca
• 机 构: MerckResearchLaboratories
• 出 处: 药物分析学报：英文版
• 发表日期: 2015年4期
• 关键词: 衍生化气相色谱法 定量分析方法 脂肪酸 油酸 验证 火焰离子化检测器 GC-FID 毛细管色谱柱 Oleic acidFatty acidsGas chroma
• 基金项目: The authors would like to acknowledge Yu-Chien Wei, Hui Liu, Joy Jin, Tina Masiuk, Maureen Marsales, Justin Pennington and Brent Donovan for productive discussions.

Oleic acid is a common pharmaceutical excipient that has been widely used in various dosage forms. Gas chromatography(GC) has often been used as the quantitation method for fatty acids normally requiring a derivatization step. The aim of this study was to