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本文观察了ＮＯ抑制剂对小肠、脑、心、肺、脾、肝、肾、肾上腺、胸腺的形态学改变，结果表明，单用ＬＰＳ或ＮＡＭＥ１ｈ内均未见脏器明显病理改变，但ＬＰＳ＋Ｌ一ＮＡＭＥ１ｈ后，即可引起肠管紫绀，肠腔大量出血；组织学检查，小肠、肺呈弥慢性出血，肾、脾呈梗塞性坏死，但心、肝变化不明显。延长观察时间，单独注射Ｌ一ＮＡＭＥ２ｈ，小肠绒毛毛细血管明显充血扩张，６ｈ后可见绒毛内毛细血管内皮损伤，局部出血。但Ｄ一ＮＡＭＥ并不引起同样病变。本研究表明，ＮＯ释放对维持内皮细胞在病理或正常条件下的完整性具有重要意义。
In this paper, morphological changes of small intestine, brain, heart, lung, spleen, liver, kidney, adrenal gland and thymus were observed. The results showed that no obvious pathological changes were found in LPS or NAME1h, but LPS + NAME1h, you can cause intestinal cyanosis, a large number of intestinal bleeding; histological examination, small intestine, pulmonary diffuse chronic hemorrhage, renal, splenic infarction necrosis, but the heart and liver changes were not obvious. Extend the observation time, L-NAME2h injection alone, small intestine villus capillaries significantly congestion and expansion, 6h after visible villus capillary endothelial injury, local bleeding. However, D-NAME does not cause the same disease. This study shows that NO release is important for maintaining the integrity of endothelial cells under pathological or normal conditions.