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Conventional optical tweezers based on traditional optical microscopes are subject to the diffraction limit,making the precise trapping and manipulation of very small particles challenging.Plasmonic optical tweezers can surpass this constraint,but many potential applications would benefit from further enhanced performance and/or expanded functionalities.In this Perspective,we discuss trends in plasmonic tweezers and describe important opportunities presented by its interdisciplinary combination with other techniques in nanoscience.We furthermore highlight several open questions conceing fundamentals that are likely to be important for many potential applications.