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目的评价氟西汀联合短疗程黛力新治疗脑卒中后抑郁的疗效。方法选择96例脑卒中后抑郁的患者随机分为3组,分别接受氟西汀联合黛力新、氟西汀、多虑平治疗。观察3组治疗前与治疗后1周、4周汉密顿抑郁量表(HAMD)评分及日常生活活动能力测定(ADL)评分的变化,并观察3组的不良反应。结果 1周后,氟西汀联合黛力新组疗效好,与其他2组相比有显著差异性(P<0.05),4周时的评价结果,氟西汀联合黛力新组与单用氟西汀组疗效相当,均显著优于多虑平组。不良反应的观察提示,氟西汀联合黛力新组有一定不良反应,但发生率低且症状轻微,多虑平组发生率高且症状较重。结论氟西汀联合黛力新治疗脑卒中,疗效更优,且降低了不良反应的发生率,为临床用药提供了一定的参考依据。
Objective To evaluate the efficacy of fluoxetine combined with a short course of dextrine in the treatment of post-stroke depression. Methods Ninety-six patients with post-stroke depression were randomly divided into three groups, receiving fluoxetine combined with deacetylene, fluoxetine and doxepin respectively. The changes of HAMD score and ADL score of the three groups before and after treatment for 1 week and 4 weeks after treatment were observed. Adverse reactions were observed in 3 groups. Results After 1 week, fluoxetine combined with dexamethasone was effective, with significant difference compared with the other two groups (P <0.05). After 4 weeks, fluoxetine combined with dexamethasone group and single use Fluoxetine treatment group was equivalent, were significantly better than doxepin group. Adverse reactions observed, fluoxetine combined with dexmede new group has some adverse reactions, but the incidence is low and the symptoms are mild, doxepin group incidence and severe symptoms. Conclusion Fluoxetine combined with Deanxit treatment of stroke, better efficacy, and reduce the incidence of adverse reactions, providing some reference for clinical use.