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利福平(refampicin,下简称RFP)是利福霉素B的一种衍生物,其抗菌力强,抗菌谱广,低浓度抑菌,高浓度杀菌。它对结核杆菌、多数革兰氏阳性菌有强大快速的抗菌作用,对麻风杆菌.某些革兰氏阴性菌有抑菌作用。利福平自60年代问世以来,国外对其药效学,药动学进行了深入的研究。国内这方面的研究报告很少。本文重点介绍RFP在人体内的药代动力学,为临床医师合理使用RFP提供参考。
Refampicin (RFP), a derivative of rifamycin B, has strong antibacterial activity, broad antimicrobial spectrum, low concentration of bacteriostasis and high concentration of bactericidal activity. It is Mycobacterium tuberculosis, most Gram-positive bacteria have a strong and rapid antibacterial effect on the leprosy. Some Gram-negative bacteria have antibacterial effect. Since the advent of the rifampicin in the 1960s, its pharmacodynamics and pharmacokinetics have been deeply studied abroad. Domestic research reports in this area are few. This article focuses on the pharmacokinetics of RFP in humans and provides a reference for clinicians to use RFP rationally.