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目的探讨壹期矽肺患者血清中巨噬细胞炎症蛋白-1α(MIP-1α)、巨噬细胞炎症蛋白-1β(MIP-1β)和巨噬细胞炎症蛋白-3α(MIP-3α)水平变化及其与肺功能关系。方法用Luminex流式荧光技术检测55例壹期矽肺(矽肺组)、35例具有与矽肺组相同接尘条件的健康井下接尘矿工(接尘组)和33例非接尘井上健康人员(对照组)血清中MIP-1α、MIP-1β和MIP-3α水平;用肺功能机检测用力肺活量(FVC%)、1秒钟用力呼气量(FEV_(1.0)%)、用力呼气1秒率(FEV_(1.0)/FVC%)、最大呼气中期流速(MMEF 75/25%)4项肺功能指标。结果与对照组比较,接尘和矽肺组血清中MIP-1α水平均明显降低,接尘组MIP-1β水平也明显降低,差异均有统计学意义(均P<0.01);与接尘组比较,矽肺组血清中MIP-1α和MIP-1β水平均显著升高,差异均有统计学意义(均P<0.01);吸烟矽肺患者血清中MIP-1β水平低于非吸烟矽肺患者,差异有统计学意义(P<0.05);矽肺组4项肺功能指标明显低于接尘组,差异均有统计学意义(均P<0.01);矽肺组MIP-1α与FVC%、MIP-1α与FEV_(1.0)%均呈正相关(r=0.330、0.324,P<0.05)。结论壹期矽肺患者血清中MIP-1α和MIP-1β水平异常,二者参与壹期矽肺发生发展;吸烟影响MIP-1β水平;MIP-1α水平可间接反映肺功能。
Objective To investigate the changes of serum levels of MIP-1α, MIP-1β and MIP-3α in patients with silicosis Ⅰ Relationship with lung function. Methods Luminex flow cytometry was used to detect 55 cases of stage I silicosis (silicosis group), 35 healthy underground dust miners (dust exposure group) and 33 healthy non-dust wells (control group (FVC%), forced expiratory volume (FEV_ (1.0)%) for 1 second, forced expiration for 1 second, the rate of MIP-1α and MIP- (FEV_ (1.0) / FVC%), maximum expiratory mid-term flow rate (MMEF 75/25%) four pulmonary function indicators. Results Compared with the control group, the levels of MIP-1α in serum of the dust-exposed group and the silicosis group were significantly decreased, while the levels of MIP-1β in the dust-exposed group were also significantly decreased (all P <0.01) , Serum levels of MIP-1α and MIP-1β in silicosis group were significantly increased, the differences were statistically significant (all P <0.01); serum levels of MIP-1β in smokers with silicosis were lower than those in nonsmokers (P <0.05). The four indexes of pulmonary function in silicosis group were significantly lower than those in control group (all P <0.01). There was no significant difference between MIP-1α and FVC%, MIP-1α and FEV_ 1.0)% respectively (r = 0.330,0.324, P <0.05). Conclusions Serum levels of MIP-1α and MIP-1β are abnormal in stage I silicosis, both of which are involved in the development of silicosis in stage I. Smoker affects the level of MIP-1β. MIP-1α level indirectly reflects lung function.