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一种新近研究出的抗疟药,甲氟喹(mefloqu ine)表明对体外的派特丝虫和马来丝虫的幼虫和成虫有杀虫效能。在2～10μM浓度范围内,使丝虫于10小时～3天内麻痹至死。甲氟喹的致死作用系使幼虫和成虫失去活动能力,并使成虫乳酸盐分泌降低所致。麻痹效果与浓度和时间有关。派特丝虫微丝蚴置于2、5和10μM的甲氟喹浓度下,分别在3天、2天和10小时内失去活动性;而两种成虫在1、
A newly developed anti-malarial drug, mefloquine, shows insecticidal efficacy against larvae and adults of Petite and Malay filaments in vitro. In the 2 ~ 10μM concentration range, the filarial paralysis to death within 10 hours to 3 days. The lethal effect of mefloquine deprives larvae and adults of their ability to act and the secretion of lactate from adults decreases. Paralysis effect and concentration and time. Paecil filarial microfilariae were exposed to mefloquine concentrations of 2, 5, and 10 μM, respectively, and lost activity within 3 days, 2 days and 10 hours, respectively. However,