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急性缺血性脑血管病是神经科常见病。近年来发现此类患者脑脊液(CSF)中β—内啡肽(β—EP)含量明显增高,并在动物实验中得以证实。而阿片肽受体阻滞剂——纳洛酮可逆转脑梗塞患者及动物的部分神经系统缺损症状。故认为β—EP参与缺血性脑血管病急性期有害的病理生理过程。但目前尚无大量观测脑梗塞患者急性期不同阶段CSF中β—EP含量变化过程的报告。我们连续测定了46例急性脑梗塞患者CSF中β—EP含量,现报告如下。
Acute ischemic cerebrovascular disease is a common neurological disease. In recent years, these patients were found in cerebrospinal fluid (CSF) β-endorphin (β-EP) was significantly increased, and confirmed in animal experiments. Opioid receptor blockers - naloxone reverses some of the neurological deficits in patients with cerebral infarctions and in animals. Therefore, it is considered that β-EP is involved in the pathophysiological process of acute phase of ischemic cerebrovascular disease. However, there is not a large number of reports on the changes of β-EP in different stages of acute phase of cerebral infarction. Our continuous determination of 46 cases of acute cerebral infarction in the CSF β-EP content, are as follows.