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目的:探索三苯氧胺配伍米索前列醇终止早孕的可能性。方法:给84例停经≤49天孕妇服用不同剂量三苯氧胺进行临床预试验。两组分次服80mg和160mg三苯氧胺,然后阴道用80μg米索前列醇。结果:①160mg三苯氧胺和米索前列醇联合应用成功率为90％。其出血天数为8～9天,未见副作用。②160mg三苯氧胺组的完全流产率高于80mg三苯氧胺组。结论:三苯氧胺合并阴道用米索前列醇能够有效终止早孕,其方法有待进一步探索。
Objective: To explore the possibility of termination of early pregnancy with tamoxifen and misoprostol. Methods: 84 cases of menopause ≤ 49 days pregnant women taking different doses of tamoxifen clinical pre-test. Two sets of sub-doses of 80mg and 160mg tamoxifen, and vaginal with 80μg misoprostol. Results: ① The success rate of combination of 160mg tamoxifen and misoprostol was 90%. The bleeding days for 8 to 9 days, no side effects. ② 160mg tamoxifen group, the complete abortion rate was higher than 80mg tamoxifen group. Conclusion: Tamoxifen combined vaginal misoprostol can effectively terminate early pregnancy, its method needs to be further explored.