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骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSCs)是成体干细胞的一种,具有来源丰富,容易分离及培养,分化和增殖能力强,免疫原性低、可自体移植等优点,已被作为“种子细胞”广泛应用于组织工程、细胞治疗和基因治疗的研究中。而Wnt信号通路在控制心血管胚胎细胞的分裂、增殖、迁移和分化等生物学功能中扮演着重要的角色;另外,在某些因素的影响下它能促进或阻止内皮细胞及心肌细胞的凋亡和损伤。此外,研究发现Wnt信号通路的各组分在BMSCs均有表达,提示Wnt信号通路在维持BMSCs的增殖
Bone marrow mesenchymal stem cells (BMSCs) is a kind of adult stem cells, which has many advantages such as rich source, easy separation and culture, strong differentiation and proliferation ability, low immunogenicity and autologous transplantation. “Seed cells ” is widely used in tissue engineering, cell therapy and gene therapy research. The Wnt signaling pathway plays an important role in controlling biological functions such as division, proliferation, migration and differentiation of cardiovascular embryonic cells. In addition, Wnt signaling pathway can promote or prevent the apoptosis of endothelial cells and cardiomyocytes under the influence of some factors Death and damage. In addition, the study found that Wnt signaling pathway components in BMSCs are expressed, suggesting that Wnt signaling pathway in maintaining the proliferation of BMSCs