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目的:评估我国5种探亲避孕药的有效性、副反应、安全性及可接受性。方法:检索相关文献并对纳入评估系 统的探亲避孕药进行数据分析。结果:共检索到50篇相关文献,11篇文献被纳入本评估,其中4篇为无对照的临床 试验,7篇为一期临床试验。根据有限的资料分析,探亲避孕片1号及53号探亲抗孕片早期服用方案的避孕失败率 在3.5～16.4/100妇女年之间。一期临床试验显示服用53号探亲抗孕片后并不能完全抑制排卵。53号探亲抗孕片 还可能抑制乳汁分泌。未检索到探亲避孕片1号及53号探亲抗孕片现用方案及炔诺孕酮速效避孕片、左炔诺孕酮速 效避孕片和炔诺酮探亲丸临床资料。结论:建议在较短时间内逐渐停止使用探亲避孕药。如果需要保留部分探亲避 孕药,需要对其有效性、副反应、安全性重新进行研究。
Objective: To evaluate the effectiveness, side effects, safety and acceptability of five types of contraceptives in China. Methods: Retrieval of relevant literature and data analysis of visiting family planning contraceptives included in the assessment system. RESULTS: A total of 50 related articles were retrieved and 11 articles were included in this assessment. Four of them were uncontrolled clinical trials and seven were phase I clinical trials. According to the limited data analysis, the contraceptive failure rates of probing for contraceptives No. 1 and No. 53 for visiting relatives during early pregnancy were between 3.5 and 16.4 per 100 women years. Phase I clinical trials showed that taking 53 and visiting anti-pregnancy tablets does not completely inhibit ovulation. 53 to visit relatives and anti-pregnancy may also inhibit milk secretion. No access to the pro-family contraceptives No. 1 and No. 53 to visit the pro-active anti-pregnancy program and contraceptive tablets norvenprogesterone, levonorgestrel effective contraceptive tablets and norethindrone pro-pro-drug clinical data. Conclusion: It is recommended to gradually stop using the contraceptive pills in a relatively short period of time. If you need to retain some of the visiting contraceptives, the need for its effectiveness, side effects, safety re-study.